East Carolina University's Psychophysiology Lab was first to establish the mood altering and cognitive effects of casual video games using unique psychophysiological and neuroendocrine methods. Simultaneously, we were developing new biofeedback techniques to use with returning Wounded Warrior Marines. We learned how to incorporate sensor technology and biofeedback techniques into casual video games. Preliminary data indicated "biofeedback games" could exercise the autonomic nervous system, increasing its control and subsequently decreasing stress and improving overall performance. These developments have led to 3 current Department of Defense (Telemedicine and Technology Research Center) grants designed to develop a (game based) naturalistic assessment for head trauma and biofeedback games for the Warfighter for preventing stress related conditions such as PTSD.